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Tuesday, July 18, 2017

Case Study and Case Report 2017; 7(3): 65 - 75.

Salmanoglu E, Kurutas EB. Effects of 99mTc-MDP bone scintigraphy on
oxidative/nitrosative stress biomarkers in patients. Case Study Case Rep. 2017; 7(3): 65 - 75

We aimed to define the effects of Technetium-99m Methylendiphosphonate bone
scintigraphy on oxidative/nitrosative stress in patients after intravenous injection and
compared to healthy control group. Forty patients for bone scintigraphy and forty healthy
control group were included this study. The age range was similar in both groups (18-74
years). The blood samples were taken from patients 2 hour after intravenous injection of 20
mCi (740 MBq) Technetium-99m Methylendiphosphonate. The activities of catalase,
superoxide dismutase and malondialdeyhde levels were measured as oxidative stress
biomarkers and nitric oxide and nitrotyrosine levels were measured as nitrosative stress
biomarkers in patients and control group. There were no significant differences according to
both age and sex between two groups (p˃0.05). Activities of catalase and superoxide
enzymes and malondialdeyhde levels in patients were increased in patients compared to
controls (p<0.05). Also, nitric oxide and nitrotyrosine levels in patients were higher than
control group (p<0.05). Technetium-99m Methylendiphosphonate may cause both oxidative
and nitrosative stress in patients. Also antioxidant defense of the patients was higher
compared to healthy subjects possibly due to a compensatory response to ionising radiation in
the living cells and thereby protects the cells against oxidative/nitrosative damage.
Keywords: Bone scintigraphy, oxidative/nitrosative stress, catalase, superoxide dismutase,
malondialdehyde, nitric oxide, nitrotyrosine

Saturday, July 8, 2017

Case Study and Case Report 2017; 7(3): 53 - 64.

Mól N, Ptak K, Zasada M, Końska K, Pilch M, Knapp A, Kwinta P. Hunter Syndrome complicated by a communicating hydrocephalus and arachnoid cysts at a very young age. Case Study Case Rep. 2017; 7(3): 53 - 64.


Mucopolysaccharidosis type II (MPS II) is an X-linked recessive lysosomal storage disease caused by deficient activity of iduronate 2-sulfatase, which regulates  lysosomal catabolism of the glycosaminoglycans. As a consequence, undegraded dermatan and heparan sulfates accumulate in all the tissues and organs of the body, including the central nervous system, where they cause irreversible changes. Some of the neurological manifestations include behavioral problems, mental retardation or cognitive deterioration, ventriculomegaly, hydrocephalus, compressive myelopathy, seizures or hearing loss. This report describes an infant boy diagnosed with MPS II who presented with an acute communicating hydrocephalus and arachnoid cysts at 9 months of age. The patient was diagnosed with MPS II shortly after birth because of his positive family history. At that time he did not present any physical manifestation of the disease, all the imaging studies of the head, abdomen and cardiac function were normal. He was started on enzyme replacement therapy with Elaprase®, which he received every week at our Clinic. Such frequent visits allowed for an immediate diagnosis of sudden increase of the intracranial pressure and the timely surgical intervention. To the best of our knowledge, this is the first reported case of a patient with MPS II, who developed acute hydrocephalus requiring surgical implementation of a ventriculo-peritoneal shunt at such a young age.

Keywords: Hunter Syndrome, hydrocephalus, arachnoid cyst

Monday, June 19, 2017

Case Study and Case Report 2017; 7(3): 49 – 52.

Natekar AA, Agarwal S, Sengupta A. Cervical Aspergillosis in a post-menopausal female- A case report. Case Study Case Rep. 2017; 7(3): 49 – 52.


Fungal infections are commonly encountered in the female genital tract on routine cervical smear examination, the most common being candida. Cervico-vaginal aspergillosis infection is rarely reported. We report a case of aspergillus infection in an immunocompetent 55 year old post-menopausal female who presented with white discharge per vaginum. Initially the cervical pap smears showed only inflammatory changes. On per speculum examination the cervix appeared congested and ulcerated. Cervical biopsy was performed which showed sheets and balls of aspergillus fungus with areas of necrosis. PAS staining further confirmed the diagnosis. Serological tests performed were negative. Patient was started on antifungal and repeat biopsy from cervix did not show any fungal hyphae.

Keywords: Aspergillus, immunocompetent, cervix

Saturday, June 3, 2017

Case Study and Case Report 2017; 7(2): 46 - 48.

Tiemsiriwatt W, Chandriga S, Kuillinorman L. Anti HIV seropositive, false positive, influenza vaccination and medical sue: a story. Case Study Case Rep. 2017; 7(2): 46 – 48.


The present emerging of influenza in several countries increase the number of influenza vaccination. The increased incidence of adverse effect due to influenza vaccination can also be seen. Here, the author would like to discuss on an interesting case of non AEFI but complicated episode outcome of influenza vaccination. This is a case of medical sue due to the false positive report of Anti HIV seropositive to a healthy subjects from a medical laboratory in a private hospital.

Keywords: Influenza, vaccination, HIV

Wednesday, May 17, 2017

Case Study and Case Report 2017; 7(2): 35 – 45.

Olaifa AK, Oguntoye CO. Type I free gas bloat vagal indigestion in a 10-month old west
African dwarf goat: a case report. Case Study Case Rep. 2017; 7(2): 35 – 45.


Type I vagal indigestion, or failure of eructation, results in free-gas bloat and has been
attributed to inflammatory lesions in the vicinity of the vagus nerve, such as localized
peritonitis, adhesions (usually after an episode of traumatic reticuloperitonitis), or chronic
pneumonia with anterior mediastinitis. Bloat is an over distention of the rumen and reticulum
with the gases of fermentation. Free gas bloat is a secondary tympany where vagus
indigestion or other innervations disorders, esophageal papilloma, lymphosarcoma and
esophageal foreign bodies are examples of its causes. A 10-month old West African Dwarf
buck was presented at the Veterinary Teaching Hospital University of Ibadan with a
distended abdomen which was more towards the left side following a fight between the buck
and another buck in the same pen. The distention occurred gradually over a week. Physical
examination was performed and a left ping was heard on percussion of the distention after
which the animal was taken into the theatre for exploratory rumenotomy. When bloating
occurs, these gases cannot escape, they continue to build up and cause severe distention of
the abdomen, reflected by discomfort and acute pain, furthermore bloat cause decrease
respiratory rate due to compression of the thorax followed by Dyspnea and difficult
breathing, however the compression might affected heart lead to increase its rate and intensity
causing reduced performance, activity and death in some cases.

Keywords: Vagal indigestion, bloat, rumenotomy, buck

Sunday, May 7, 2017

Case Study and Case Report 2017; 7(2): 31 - 34.

Tiemsiriwatt W, Guillinan L. Gianotti-Crosti syndrome after Japanese encephalitis vaccination: a case report. Case Study Case Rep. 2017; 7(2): 31 – 34.


Gianotti-Crosti syndrome is an uncommon syndrome with dermatological presentation that can be self-limited. It is seen as a childhood exanthem that manifests in a characteristic acral distribution and commonly seen in post-viral infections. However, it can also be seen in cases with history of vaccination. Here, the author presents a case of Gianotti-Crosti syndrome after Japanese encephalitis vaccination.

Keywords: Gianotti-Crosti syndrome, Japanese encephalitis, vaccination

Wednesday, April 5, 2017

Case Study and Case Report 2017; 7(2): 29 - 30.

Joob B, Yasser F. Phenotypic spectrum of congenital Zika syndrome: a comment on the usefulness of case report. Case Study Case Rep. 2017; 7(2): 29 - 30.


Editorial: “Phenotypic spectrum of congenital Zika syndrome: a comment on the usefulness of case report” 

Keywords: Zika virus, spectrum, case report