Case Study and Case Report 2024; 14(2): 16 - 18.

Sant K, Sant R. Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency - First Diagnosed in Elderly Life Due to Unexplained Low Hemoglobin: A Case Report. Case Study and Case Report 2024; 14(2): 16 - 18. ABSTRACT Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a hereditary enzyme disorder that commonly manifests in infancy or early childhood, often precipitated by oxidative stress from infections, certain drugs, or food. However, in rare cases, it may remain undiagnosed until later in life. This case report presents a 72-year-old male with no previous history of hemolysis, who was diagnosed with G6PD deficiency after presenting with unexplained low hemoglobin and recurrent anemia. Initial laboratory investigations ruled out common causes such as iron deficiency or chronic disease, and further testing revealed the G6PD deficiency after a reticulocyte count and G6PD enzyme activity test were performed. The patient’s hemolysis was triggered by unidentified oxidative stress, and he responded well to supportive care. This case highlights the need for clinicians to consider G6PD deficiency in the differential diagnosis of unexplained anemia in elderly individuals, especially in those with recurrent episodes of low hemoglobin and no apparent cause. Early recognition can guide treatment decisions and prevent complications related to oxidative stress. Keywords: G6PD deficiency, Anemia, Elderly, Hemolysis